Global network activity in the brain modulates local neural circuitry via calcium signaling in non-neuronal cells called astrocytes (Fig. 1), according to research led by Hajime Hirase of the RIKEN Brain Science Institute. The finding clarifies the link between two important processes in the brain.
Development
Confirmation of repeated patterns of neurons indicates stereotypical organization throughout brain’s cerebral cortex
Neurons are arranged in periodic patterns that repeat over large distances in two areas of the cerebral cortex, suggesting that the entire cerebral cortex has a stereotyped organization, reports a team of researchers led by Toshihiko Hosoya of the RIKEN Brain Science Institute. The entire cortex has a stereotypical layered structure with the same cell types arranged in the same way, but how neurons are organized in the other orientationparallel to the brains surfaceis poorly understood.
Mild traumatic brain injury may alter the brain’s neuronal circuit excitability and contribute to brain network dysfunct
Even mild head injuries can cause significant abnormalities in brain function that last for several days, which may explain the neurological symptoms experienced by some individuals who have experienced a head injury associated with sports, accidents or combat, according to a study by Virginia Commonwealth University School of Medicine researchers.
Researchers identify genetic mutation causing rare form of spinal muscular atrophy
Scientists have confirmed that mutations of a gene are responsible for some cases of a rare, inherited disease that causes progressive muscle degeneration and weakness: spinal muscular atrophy with lower extremity predominance, also known as SMA-LED.
Think global, act local: New roles for protein synthesis at synapses
(Medical Xpress) — How do we build a memory in the brain? It is well known that for animals (and humans) new proteins are needed to establish long-term memories. During learning information is stored at the synapses, the junctions connecting nerve cells. Synapses also require new proteins in order to show changes in their strength (synaptic plasticity). Historically, scientists have focused on the cell body as the place where the required proteins are synthesized. However, in recent years there has been increasing focus on the dendrites and axons (the compartments that meet to form synapses) as a potential site for protein synthesis.