Study of fruit fly sleep reveals a genetic basis of insomnia

(Medical Xpress) — On the surface, it’s simple: when night falls, our bodies get sleepy. But behind the scenes, a series of complex molecular events, controlled by our genes, is hard at work to make us groggy. Now, research suggests that a newly identified gene known as insomniac is an important reason why we don’t stay up all night. By cloning and testing this gene in fruit flies, Rockefeller University researchers say they have discovered an entirely new mechanism by which sleep is regulated.

Discovery may lead to new treatment for Rett Syndrome

Researchers at Oregon Health & Science University have discovered that a molecule critical to the development and plasticity of nerve cells – brain-derived neurotrophic factor (BDNF) — is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder. The finding has implications for the treatment of neurological disorders, including Rett syndrome that affects one in 10,000 baby girls.

New mechanistic insights into adaptive learning

The brain is a fantastically complex and mysterious device, too large and with too many internal connections to be entirely programmable genetically. Its internal connectivity must therefore self-organize, based on the one hand on genetically regulated biases and on experience and learning on the other. The brain can change its internal connectivity based, for example, on correlations between the inputs it receives and the consequences of actions associated with those inputs, in a phenomenon we generally call associative learning. There are, in our daily life, numerous examples of this type of learning; its consequence is that a smell or a tune on the radio can trigger memories from the past, which lay dormant for some time.